![]() ![]() ![]() The live attenuated influenza vaccine is made from weakened influenza viruses and is given as a nasal spray. The inactivated influenza vaccine is made of killed influenza viruses or parts of the viruses and is given by injection. are either inactivated or live attenuated vaccines. The influenza virus can cause serious illness and even death. Portions of this document last updated: Oct.Influenza vaccines are a safe and effective way to help people stay healthy, prevent illness and even save lives. You may report side effects to the FDA at 1-80. If you notice any other effects, check with your healthcare professional.Ĭall your doctor for medical advice about side effects. Other side effects not listed may also occur in some patients. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: More commonīleeding, blistering, burning, coldness, discoloration of skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Some side effects may occur that usually do not need medical attention. Puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue Tell your doctor right away if you have a rash, itching, a fast heartbeat, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth after receiving the vaccine. This vaccine may cause serious allergic reactions, including anaphylaxis, which can be life-threatening and require immediate medical attention. Precautionsīe sure to notify your doctor of any side effects (eg, feeling faint) that occur after you receive this vaccine. It is given as a shot into one of your muscles. Immune system problems-This vaccine may not work as well in patients with a weak immune system.Ī nurse or other trained health professional will give you this vaccine. Make sure you tell your doctor if you have any other medical problems, especially: The presence of other medical problems may affect the use of this vaccine. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Other InteractionsĬertain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter ) medicine. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Drug InteractionsĪlthough certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. GeriatricĪppropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of Abrysvo™ in the elderly. Safety and efficacy have not been established. Safety and efficacy have not been established.Īppropriate studies have not been performed on the relationship of age to the effects of Abrysvo™ in infants born to women who were vaccinated at younger than 10 years of age. Appropriate studies have not been performed on the relationship of age to the effects of Abrysvo™ in non-pregnant women younger than 18 years of age. ![]()
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![]() To learn more about how and for what purposes Amazon uses personal information (such as Amazon Store order history), please visit our Privacy Notice. You can change your choices at any time by visiting Cookie Preferences, as described in the Cookie Notice. Click ‘Customise Cookies’ to decline these cookies, make more detailed choices, or learn more. ![]() Third parties use cookies for their purposes of displaying and measuring personalised ads, generating audience insights, and developing and improving products. 1 (2003) Official Trailer - Uma Thurman, Lucy Liu Action Movie HD Rotten Tomatoes Classic Trailers 1.56M subscribers Subscribe 18K Share 3. This includes using first- and third-party cookies, which store or access standard device information such as a unique identifier. If you agree, we’ll also use cookies to complement your shopping experience across the Amazon stores as described in our Cookie Notice. Four years after taking a bullet in the head at her own wedding The Bride (Thurman) emerges from a coma and decides its time for payback. ![]() We also use these cookies to understand how customers use our services (for example, by measuring site visits) so we can make improvements. Volumen 1 o Kill Bill 1 (Kill Bill: Volume 1 en inglés) es la primera parte de las dos películas de Kill Bill escritas y dirigidas por el gran Quentin Tarantino. Kill Bill 1 Addeddate 07:37:17 Identifier kill-bill-1 Scanner Internet Archive HTML5 Uploader 1.7.0. Uma Thurman (Pulp Fiction) stars in this action-packed thriller about brutal betrayal and an epic vendetta. We use cookies and similar tools that are necessary to enable you to make purchases, to enhance your shopping experiences and to provide our services, as detailed in our Cookie Notice. Beatrix 'the Bride' Kiddo (codename: Black Mamba) is the protagonist of the martial arts films Kill Bill: Volume 1 (2003) and Kill Bill: Volume 2 (2004), directed by Quentin Tarantino.She is portrayed by Uma Thurman. ![]() ![]() ![]() You may select from Clear Glass or Starphire Ultra Clear Glass. This design is available with several Base options and Live Edge Slabs, and can be paired with various glass shapes. 96 x 48 x Ultra Clear Starphire Glass Top. Oregon Big Leaf Maple Burl Live Edge Wood Slab. Please visit our showroom in Annville to see all available options, but here are a few popular coffee table styles that we carry. Double L Base in Polished Stainless Steel. Our delivery crew can setup and place your living room furniture in your home for you too. You’ll find work by The Wright Edge throughout the entrance, lobby, desks, and restaurant. We were honored to be showcased at the Delta Hotel in Allen, TX, where you’ll find countless one of a kind live edge tables and custom woodworking pieces crafted by hand. Local and nationwide delivery is available. THE WRIGHT EDGE SHOWCASE AT THE DELTA HOTEL BY MARRIOT. Wood options for our coffee tables: Maple, Cherry, Rustic cherry, Oak, and Quartersawn white oak. Our design experts are here to help you choose the options for your coffee table that are best suited to your needs. Handmade in Sheffield from solid oak, 60mm glass and raw steel The wood pictured is finished in OIL - other choices are available Dimensions-Length. You're able to select the wood, stain or paint, distressing/finishing style, hardware, and more. ![]() Coffee table contains glowing in the dark resin fill in, which gives the. The great thing about these coffee tables is that if you don't see something you like on our showroom floor, you can build your own custom coffee table from a set of custom options. Modern coffee table build in live edge river glass style with industrial legs. Shop now for notable deals on wholesale round wood coffee tables.Looking to replace your living room coffee table? Home Soft Things Solid Cedar Roots Rustic Coffee Table, 40' x 20' x 20.6' Height Plant Stand Natural Wood Tree Stump Accent Trunk Live Edge Side Table with 4 Metal Legs. Find amazing deals which allow you to get more for less. Wholesalers on provide you with many options for live edge coffee tables. Knotty wood forms are pieced together to create. You can also find fast-selling wholesale outdoor coffee tables, nesting tables, ottoman coffee tables, and other modern coffee tables with practical designs at affordable prices. Mid 20th Century Free Form Live Edge Burl Coffee Table With Glass Top For Sale. Wholesale black coffee tables, on the other hand, are made to stand out. Each tabletop is unique no 2 tops will be exactly alike. These tables make a strong industrial modern statement in your living space. Buy hunarmonk Live Edge Centre Table Coffee Table Centre Table with Glass top Solid Wood Coffee Table for Rs.17000 online. These tables often come with related accessories such as many designs of chairs, stools, or sofas. 12:06:51 Opens in a new tab Opens in a new tab Opens in a new tab Opens in a new tab This Industrial styled collection features solid wood tops with wood veneers. SOLD - Live Edge Coffee Table, Ash Coffee Table, Slab Table, 20 off Rustic Table, Live Edge Table, Chunky Handmade Table, Reclaimed Wood. Can equally be used as a bench or console table. Wholesale white coffee tables are a popular option used in many houses with a white or crimson theme. Solid English Walnut live edge coffee table. Wholesale live edge coffee tables are fast selling products. 'Waterfall' Live Edge Coffee Table With Black Stained Leg, White Oak by URBAN LUMBER Co. Versailles Seared Wood Coffee Table, HGSX204 by Nuevo (1) 1,655. Versailles Oxidized Grey Wood Coffee Table by Nuevo (243) SALE. Wholesale square coffee tables, just like their rectangular counterparts, can be used in various ways to serve more than their basic purpose. Burch Coffee Table, Live Edge Top by Luxury Seating and Decor. You can now order different kinds of wholesale small tables for use in special corners of the house or office. Pick from a large variety of featured wholesale products made available here. You can also find wholesale small coffee tables and other corresponding accessories for every kind of living room or office. So much more than a surface for mugs and TV remotes, coffee tables offer all sorts of potential to brighten up your living room. Buy wholesale coffee tables with storage for living rooms and offices, where there is a need for storage compartments. All wholesale live edge coffee tables can be used for a variety of purposes. ![]() ![]() ![]() Rich in vitamin BĪdditionally, vitamins are found in the vegetable. ![]() Hearts of palm contain anti-cancer properties with antioxidants including chlorogenic acid with anti-carcinogenic properties. Antioxidants potentially prevent and repair damages caused by oxidative stress. Vitamin A is essential for preserving eyesight.Vitamin K is an anticalcification, anticancer, bone-forming and insulin-sensitizing molecule.Beta Carotene supports healthy eye function.Potassium serves as an electrolyte and helps regulate blood pressure.Magnesium contributes to the structural development of bone.Phosphorus is key for maintenance of normal pH.Iron is necessary for physical growth, neurological development, and cellular function.Folate contributes to healthy fetus development.High in nutrientsĪccording to Lawson, the heart of palm contains many essential nutrients and minerals. It’s a prebiotic that promotes the growth of good bacteria in your gut,” she says. Fiber is also highly beneficial for your digestive health. “The powerful duo of dietary fiber and plant-based protein in heart of palm keeps you feeling full which promotes weight loss. The best thing about plant-based fiber is that you can eat a lot and still lose weight. Lawson says this makes the heart of palm a great option for folks trying to lose weight. ”Hearts of palm help with repairing the damaged tissues of your body,” says Lawson. Hearts of palm are low in calories and high in protein, containing 17 amino acids, including all nine essential amino acids that can’t be made by the body and have to be obtained through diet.( Those are histidine, isoleucine, lysine, methionine, phenylalanine, threonine, threonine, valine, and tryptophan.)īecause of this, says Clara Lawson, a registered dietitian nutritionist at USA Hemp in Portland, OR, hearts of palm makes a great post-workout snack or meal. It also helps you metabolize fat in your diet, which can lower risk of heart disease. It contains antioxidants such as chlorogenic acid which helps regulate blood sugar and lipids, which helps regulate your weight and also lowers your risk of obesity, and diabetes. The palm heart is a food that helps lower blood sugar, which is key for healthy metabolism, and can help regulate insulin (meaning pre-diabetics and diabetics should eat more of it). ![]() Here are the many health benefits of eating heart of palm. Heart of palm is packed with nutrients and low in calories, while delivering a hefty dose of protein, fiber and nutrients that can lower blood sugar and even help fight cancer cells in the body. ![]() ![]() ![]() A potent rush-hour rainstorm has swamped the New York metropolitan area. 29, 2023, in the Brooklyn borough of New York. ![]() Pedestrians walk along a flooded sidewalk, Friday, Sept. It is now destroyed.Ĭity officials said they received reports that six basement apartments that flooded Friday, but all the occupants got out safely. After the family’s deaths in 2021, the basement was turned into a recreation room. Within minutes, water filled the building’s basement nearly to the ceiling. It became too dangerous to leave: “Outside was like a lake, like an ocean.” And on Friday, water began lapping against the front door of her building in Woodside, Queens. Ida killed three of Joy Wong’s neighbors, including a toddler. Although no deaths or severe injuries have been reported so far from Friday’s storm, it stirred frightening memories. The deluge came two years after the remnants of Hurricane Ida dumped record-breaking rain on the Northeast and killed at least 13 people in New York City, mostly in flooded basement apartments. Kennedy Airport surpassed its record for any September day, a bar set during Hurricane Donna in 1960, the National Weather Service said. The nearly 8 inches (20 centimeters) at John F. NEW YORK - Rain walloped the New York metropolitan area with a startling punch Friday, knocking out several subway and commuter rail lines, stranding drivers on highways, flooding basements and shuttering a terminal at LaGuardia Airport in one of the city’s wettest days in decades.Īlmost 7 inches (18 centimeters) of rain had fallen in parts of Brooklyn by midday, with at least one spot seeing 2.5 inches (6 centimeters) in a single hour, according to weather and city officials. The deluge Friday shut down swaths of the subway system, flooded some streets and highways, and cut off access to at least one terminal at LaGuardia Airport. ![]() The Biden administration has pledged to tackle climate change but this week it was being criticized by environmental groups after resuming drilling auctions for oil and gas exploration.Updated: SeptemPublished: September 29, 2023Ī man works to clear a drain in flood waters, Friday, Sept. New York city’s resilience to flooding is under scrutiny this is the second time in recent weeks that subway stations and streets have been submerged with flood water. More than 61,000 homes and businesses in New Jersey were without electricity by 6am. “There’s a lot of hurt in New Jersey,” Murphy told ABC’s Good Morning America on Thursday as he discussed damage caused by flooding in the northern part of the state and tornadoes in the southern part of the state.Īll Amtrak service between Philadelphia and Boston with an initial departure before 9am ET Thursday was canceled, and regional train service connecting New York City with Long Island was suspended. The New Jersey governor, Phil Murphy, declared a state of emergency in all of New Jersey’s 21 counties, urging people to stay off the flooded roads. Terminal B of Newark, one of the major airports serving NYC/NJ, looks like a giant swimming pool □ /XHTzC36Vtm- Dr. The NWS office in New York declared its first set of flash flood emergencies in the region Wednesday night, an alert level that is reserved for “exceedingly rare situations when a severe threat to human life and catastrophic damage from a flash flood is happening or will happen soon”. Videos posted online showed subway riders standing on seats in cars filled with water. Subway stations and tracks became so flooded that the Metropolitan Transportation Authority suspended all service, but some trains were running with limited service Thursday morning. New York’s FDR Drive, a major artery on the east side of Manhattan, and the Bronx River Parkway were under water by late Wednesday evening. They were pronounced dead at the scene, police said. The deaths in New York included a 50-year-old man, a 48-year-old woman and a two-year-old boy who were found unconscious and unresponsive late Wednesday inside a home. Officials outside of Philadelphia reported “multiple fatalities”, saying no additional details were immediately available. Unfortunately, the car was overtaken by the waters, and the firefighters who were being dragged down under the vehicle were unable to get him out,” Lora told WCBS-TV. “His family was rescued, they were all in the same car. The city’s mayor, Hector Lora, said a 70-year-old man was swept away. Five people were found dead in an apartment complex in Elizabeth, New Jersey, the city’s mayor and spokesperson told local media.Īnother death was reported in in New Jersey in the city of Passaic. A New York City police spokesperson said a total of eight people died when they became trapped in flooded basements. ![]() ![]() ![]() Nimble’s fleet of AI-powered robots intelligently pick, pack, and handle millions of products, from apparel and electronics to health and beauty, general merchandise and consumer packaged goods (CPG) for iconic brands like Best Buy, Victoria’s Secret, PUMA, iHerb, Adore Me and others. Nimble’s mission is to invent the autonomous supply chain using next-gen AI robotics to power the future of fast, efficient, and sustainable commerce. “Our robust due diligence process showed that Nimble has a clear technology lead on the incumbents and has an extraordinary opportunity to be the next generation leader in the industry.” “With E-commerce and warehouse automation continuing to exhibit incredible growth, we were attracted to Nimble’s industry leading AI robotic technology and 3PL fulfillment capabilities,” said Stephen Weiss of Cedar Pine LLC. This first-principles approach unlocks a completely new type of autonomous warehouse that's simpler, smaller, faster and more efficient than the best warehouses in the world today," Kalouche added. Rather than inefficiently retrofitting warehouses that were designed for people, we're completely reimagining and reinventing the warehouse to be conducive to robots – where robots can go and what robots can do. At Nimble, we've built intelligent robots that automate the hardest manual task in the warehouse, the unit-picking and packing process. We believe that approach leads to a suboptimal solution design – one with marginal gains and very high integration costs which ultimately dilutes the ROI. They’re taking legacy old-school warehouse concepts that were designed around the ergonomics, safety and productivity of people and trying to automate each manual process one step at a time. “Many companies are working to incrementally automate the warehouse. Our autonomous fulfillment centers and 3PL service will give brands access to state-of-the-art robotic fulfillment systems in a cost-effective way without large upfront investment,” said Nimble’s Founder and CEO Simon Kalouche. Brands want to leverage robotics and automation solutions to address this issue but are often challenged by the economics. “Finding and retaining warehouse labor, while meeting a 2-day delivery standard, is our customer’s number one operational problem. population coverage in 1-2 days and click-to-collect savings of up to 40% compared to legacy 3PL providers. ![]() Nimble's network of robotic warehouses will provide brands 96%+ U.S. Nimble's intelligent robotic fulfillment systems will autonomously pick, pack and ship eCommerce orders while reducing warehouse size by up to 75%. Building Nimble’s technological advancements are world-class engineers from NASA, SpaceX, Tesla, Boston Dynamics, GoogleX as well as Stanford, Carnegie Mellon and MIT. To scale its robotic 3PL fulfillment service Nimble has assembled a team of leading executives who have scaled logistics operations at Amazon. The additional funds bring total capital raised to $115 million.īuilding on five years of experience in robotic eCommerce fulfillment, the fresh capital will further Nimble’s goal of building a nationwide network of next-generation autonomous 3PL fulfillment centers. ![]() SAN FRANCISCO-( BUSINESS WIRE)- Nimble, an autonomous logistics and AI robotics company, announced today that it has raised $65 million in a Series B financing round led by Cedar Pine, with participation from existing investors DNS Capital, GSR Ventures, and Breyer Capital, among others. ![]() ![]() I'm not very into the HOI4/PDX community nowadays besides the TK one. And if there are more channels like that, then 100% my bad. Most people don't like that kind of content that you desire, if they did then there would be more channels that have that. People just have different tastes and it's just so weird to me how "offended" you seem and "personally disgusted" by them to make such an angry comment without any actual constructive criticism to it. And there's nothing wrong with that.īut you can't deny that a lot of people like this kind of content and it clearly works with a decently sized audience. It's just not what reddit likes or this kind of community. I started working on TK videos from when the channel had 200 subscribers, this content was never popular on reddit and it would always be downvoted. There's nothing wrong with that and it's not your type of content.īut to me it makes no sense that your opinion is popular at all outside of Reddit. I think you clearly don't like this kind of content or stuff. Starting with the comment made by u/NurRauch: I could easily be biased but I do want to leave my take on it.Īlso I'm terrible at Reddit so bare with my formatting of the post. ![]() I edit TommyKay's videos so there's an FYI. How to shoot time-lapse videos in Paradox Games.Īlright just to clear up before commenting.4Chan's Image Guide- Which Paradox game do I choose?.A full list of guides can be found here.Result: Paradox is Swedish" Websites and Wikis Please use proper spoiler formatting if you are going to discuss spoiler content in non-spoiler threads: >!Paradox is Swedish!< Please mark a thread for spoilers if there's spoilers in the main post or if there's going to be open discussion of spoilers in the comments To avoid spoiling narrative surprises for others, please adhere to the following guidelines: Users may only make one self-promotional submission per week.Īvoid topics on the list of common topics, and do not post topics on the list of banned topics.Ĭontent that breaks the spirit of these rules, or content deemed by the moderators as low-quality, may be removed at moderator discretion. Explanations should be posted as a reddit comment - referencing the title is not enough.Īll giveaways, surveys, and petitions must be approved by the moderators first. General discussion of piracy or leaked content is allowed.Īdhere to the Reddit content policy and the reddiquette.Įxplain what you want people to look at when you post an image. No links to pirated materials, pirated game mods, or key resellers. No memes, image macros, reaction pictures, or similar. Just the title of the post being relevant does not qualify. Hover your mouse over any of the boxes below to view relevant information.Games similar to Paradox titles may also be discussed. about any game published by Paradox Interactive or their partners. ![]() This is a sub-reddit for discussion, links, etc. Sales Game Converters Game Mods Flair Guide Wikis Paradox Forums Report Bug Teamspeak Discord Welcome to Paradox Plaza ![]() ![]() Being among the pioneers of country –rock music, the group received some airplay, which made one of their songs rise to number 21 on the Billboard top 40. They worked as a group of four on only one album, in 1967’s Headquarter.in 1969, he formed the First National Band where he wrote most of the band’s songs. The Monkees took control of their records and song choice when they succeeded in ousting supervisor Don Kirshner. Once the cast was done, ’Screen Gems’ bought his songs for use in the show. ![]() He was part of a singing band, ‘The Monkees,’ which was in an acting series in the same name. He recorded different songs signed by different producers before he landed an acting role at a T.V. Nesmith developed a habit of writing poems, which became the basis of his songs. He then learned how to play the guitar and also played at various bands before moving to Los Angeles with two of his friends. Nesmith started his career right after he was out of the Air Force tour duty. His height is 6 ft tall, and his weight is 70 kg. They met with Nurit while working on ‘The Monkees.’ Age, Height, and Weightīeing born on 30 December 1942, Mike Nesmith is 80 years old as of today’s date 20th October 2023. Nesmith also has a son, Jason, which he had with his lover Nurit Wilde. Back in 1976, he married his second wife, Kathryn Bild, and in 2000, he married his third wife, Victoria, but the marriage ended after 11 years. Nesmith and his wife Phyllis Ann divorced in 1972. Christian, who was born in 1965, Jonathan born in 1968 and his daughter Jessica who was born in 1970. ![]() Nesmith married his first wife in 1964, and they were both blessed with three children. He has been married three times and has four children. Nesmith is the only child from a family of Bette Nesmith, who was a single mother. ![]() This group created, recorded, and sold lots of hit songs all across the world. While in L.A, he wone a role to act on a T.V. this happened after Nesmith had spent two years in the U.S Air Force, where he trained as an aircraft mechanic at shepherds Air Force Base. In the mid-1960s, Nesmith moved to Los Angeles to advance his career. He then started recording and performing his compositions. Nesmith went to Antonio College, where he developed a love for folk music. ![]() ![]() ![]() The sides of the triangle form the chords of the circumcircle. The unequal angle or the base of the triangle is either an acute or obtuse angle. To find the perimeter of the triangle we just have to add up all the sides of the triangle. The formula to find the area of isosceles triangle or any other triangle is: ½ × base × height. In an isosceles triangle, the height that is drawn from the apex divides the base of the triangle into two equal parts and the apex angle into two equal angles. The side of the triangle that is unequal is called the base of the triangle. ![]() In an isosceles triangle, the two sides are congruent to each other. So here are the properties of a right-angled triangle. Now that we know what a triangle and an isosceles triangle is, it’s best if we move on the question, what are the properties of an isosceles triangle. What are the Properties of an Isosceles Triangle? Here, given below, is an example of a right-angled triangle. As we already know that the sum of all the angles of a triangle is always 180, so if two of the sides of a right-angled triangle are known to us, we can find the third side of the triangle. Therefore, the two opposite sides in an isosceles triangle are equal. If two out of three sides of a triangle have equal length, then the triangle will be called an isosceles triangle. Triangles are classified into two categories based on their side and angle. We should also know that the sum of all the interior angles of a triangle is always 180 degrees. Those three line segments are the sides of the triangle, the point where the two lines intersect is known as the vertex, and the space between them is what we call an angle. We can draw a triangle using any three dots in such a way that the line segments will connect each other end to end. It is the basic or the purest form of Polygon. A triangle is a 2-dimensional closed figure that has three sides and angles. ![]() ![]() ![]() ![]() However, it's not transformative from a financial standpoint. Buying Kite meets that qualification in terms of positioning the biotech in oncology. ![]() However, the company clearly needs a bigger boost to its lineup to offset its hep C woes.ĬEO John Milligan has stated that Gilead wanted a "transformative" deal. I don't question Gilead's estimates - they're probably solid. and Europe for treating refractory aggressive non-Hodgkin lymphoma (NHL). Gilead stated that the Kite acquisition is "expected to be neutral to earnings by year three and accretive thereafter." These projections assume that axi-cel wins approval in both the U.S. As great as buying Kite Pharma should be over the long run, buying Kite isn't enough to turn things around for Gilead by itself. The primary reason that Gilead Sciences needed an acquisition was to compensate for continued sales declines for its hepatitis C franchise. But buying Kite Pharma should only be the beginning of acquisitions activity for Gilead. Adding Kite's pipeline, particularly lead candidate axicabtagene ciloleucel (axi-cel), makes Gilead an instant leader in cell therapy for treating cancer. Kite seems to have shaken off this setback for the time being, with some impressive long-term trial results showing in a handful of patients with aggressive non-Hodgkin lymphoma, with some living more than four years with complete remission.There are several reasons to like the acquisition. The same safety problem caused rival biotech Juno to axe development of its lead CAR-T product after a string of deaths in early-stage trials, switching R&D to a drug further down the pipeline. Novartis has already got its rival CAR-T therapy, Kymriah (tisagenlecleucel) on the US market ahead of Kite – but FDA approval bodes well for Gilead as it waits for a decision on “axi-cel” due before the end of November.Įvaluate Pharma predicts that sales of Kite’s drug could peak at around $7.9 billion, compared with $4.7 billion for Novartis’ CAR-T.īut there are safety concerns over Kite’s drug – it emerged in May that a patient treated with it died from cerebral oedema. This will be no mean feat considering that CAR-T treatments involve harvesting a patient’s T-cells and genetically modifying them so that they attack cancer. Gilead’s immediate plans for Kite is to increase production of the T-cell technology to an “industrial scale” and increasing manufacturing capability. As for Belldegrun, he has given no clues about his plans – however, he admitted to the Israel-based website Globes that it will be difficult to exceed his achievements at Kite. ![]() R&D chief David Chang will also get a package worth $98 million. With the deal, Gilead gets Kite’s chimeric antigen receptor T-cell (CAR-T) therapy, axicabtagene ciloluecel, which is under review in the US and Europe as a treatment for an aggressive blood cancer.Īs a result of the sale, Belldegrun is expected to net a bonus of more than $694 million thanks to shares owned and a ‘golden parachute’ payment, while chief operating officer Cynthia Buttita will get around $160 million in shares and a ‘golden parachute’. The California-based pharma said a subsidiary acquired Kite for $180 per share in a deal that has also net hundreds of millions of dollars for the cancer firm’s CEO, Arie Belldegrun and senior execs. Gilead has completed its $11.9 billion landmark acquisition of Kite Pharma, as the pharma switches focus from hepatitis C to cancer and revolutionary CAR-T therapies. ![]() |
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